RESUMO
RATIONALE: We report on a patient with mild traumatic brain injury (TBI) by follow-up diffusion tensor tractography (DTT), and observed for approximately nine monthsby serial diffusion tensor tractography (DTT). PATIENT CONCERNS: A 66-year-old male patient was injured in a car crash. Approximately four weeks after the crash, he developed a tremor in the right hand and leg. His symptoms worsened over time. DIAGNOSES: Approximately six months after the crash, he developed a mild tremor in the left hand. Nine months after the crash, he manifested severe tremor in his right hand, mild resting and intentional tremor in his left hand and both legs, and mild trunkal ataxia. INTERVENTIONS: N/A. OUTCOMES: On 3-week DTT, well reconstructed DRTTs were observed in both hemispheres, except for the thinned lower portion of the right DRTT. On 9-month DTT, the right lower DRTT had thinned compared with the 3-week DTT and showed a disruption at the upper portion. The left DRTT showed thinning in the lower portion and tearing in the upper portion compared with 3-week DTT. LESSONS: Aggravation of an injured DRTT was demonstrated in a patient with mild TBI, using serial DTT examination.
Assuntos
Concussão Encefálica/complicações , Núcleos Cerebelares/lesões , Tálamo/lesões , Acidentes de Trânsito , Idoso , Ataxia/etiologia , Concussão Encefálica/diagnóstico por imagem , Núcleos Cerebelares/diagnóstico por imagem , Imagem de Tensor de Difusão , Vias Eferentes/diagnóstico por imagem , Vias Eferentes/lesões , Seguimentos , Mãos/fisiopatologia , Humanos , Perna (Membro)/fisiopatologia , Masculino , Tálamo/diagnóstico por imagem , Tremor/etiologiaRESUMO
When neurons within the motor cortex are fatally injured, their axons, many of which project into the spinal cord, undergo wallerian degeneration. Pathological processes occurring downstream of the cortical damage have not been extensively studied. We created a focal forelimb motor cortex injury in rats and found that axons from cell bodies located in the hindlimb motor cortex (spared by the cortical injury) become secondarily damaged in the spinal cord. To assess axonal degeneration in the spinal cord, we quantified silver staining in the corticospinal tract (CST) at 1 week and 4 weeks after the injury. We found a significant increase in silver deposition at the thoracic spinal cord level at 4 weeks compared to 1 week post-injury. At both time points, no degenerating neurons could be found in the hindlimb motor cortex. In a separate experiment, we showed that direct injury of neurons within the hindlimb motor cortex caused marked silver deposition in the thoracic CST at 1 week post-injury, and declined thereafter. Therefore, delayed axonal degeneration in the thoracic spinal cord after a focal forelimb motor cortex injury is indicative of secondary damage at the spinal cord level. Furthermore, immunolabeling of spinal cord sections showed that a local inflammatory response dominated by partially activated Iba-1-positive microglia is mounted in the CST, a viable mechanism to cause the observed secondary degeneration of fibers. In conclusion, we demonstrate that following motor cortex injury, wallerian degeneration of axons in the spinal cord leads to secondary damage, which is likely mediated by inflammatory processes.
Assuntos
Córtex Motor/lesões , Córtex Motor/patologia , Medula Espinal/patologia , Animais , Benzoxazinas , Proteínas de Ligação ao Cálcio/biossíntese , Proteínas de Ligação ao Cálcio/genética , Circulação Cerebrovascular/fisiologia , Corantes , Vias Eferentes/lesões , Fluoresceínas , Corantes Fluorescentes , Membro Anterior/inervação , Membro Posterior/inervação , Imuno-Histoquímica , Masculino , Proteínas dos Microfilamentos , Microglia/patologia , Córtex Motor/irrigação sanguínea , Degeneração Neural/patologia , Fibras Nervosas/patologia , Compostos Orgânicos , Oxazinas , Perfusão , Ratos , Ratos Sprague-Dawley , Coloração pela PrataRESUMO
Phrenic nerve stimulation is a technique whereby a nerve stimulator provides electrical stimulation of the phrenic nerve to cause diaphragmatic contraction. The most common indications for this procedure are central alveolar hypoventilation and high quadriplegia. This paper reviews the available data on the 19 patients treated with phrenic nerve stimulation in Australia to date. Of the 19 patients, 14 required pacing due to quadriplegia, one had congenital central hypoventilation syndrome and one had brainstem encephalitis. Information was unavailable for the remaining three patients. Currently, 11 of the pacers are known to be actively implanted, with the total pacing duration ranging from 1 to 21 years (mean 13 years). Eight of the 19 patients had revision surgeries. Four of these were to replace the original I-107 system (which had a 3-5-year life expectancy) with the current I-110 system, which is expected to perform electrically for the patient's lifetime. Three patients had revisions due to mechanical failure. The remaining patients' notes were incomplete. These data suggest that phrenic nerve stimulation can be used instead of mechanical ventilators for long-term ongoing respiratory support.
Assuntos
Diafragma/inervação , Terapia por Estimulação Elétrica/métodos , Procedimentos Neurocirúrgicos/métodos , Marca-Passo Artificial/tendências , Nervo Frênico/cirurgia , Paralisia Respiratória/terapia , Austrália , Infartos do Tronco Encefálico/complicações , Infartos do Tronco Encefálico/patologia , Diafragma/fisiopatologia , Vias Eferentes/lesões , Vias Eferentes/patologia , Vias Eferentes/fisiopatologia , Encefalite/complicações , Encefalite/patologia , Falha de Equipamento , Evolução Fatal , Humanos , Pescoço/anatomia & histologia , Pescoço/cirurgia , Procedimentos Neurocirúrgicos/instrumentação , Nervo Frênico/anatomia & histologia , Nervo Frênico/fisiologia , Quadriplegia/complicações , Quadriplegia/etiologia , Quadriplegia/fisiopatologia , Respiração Artificial/instrumentação , Respiração Artificial/métodos , Centro Respiratório/patologia , Centro Respiratório/fisiopatologia , Paralisia Respiratória/etiologia , Paralisia Respiratória/fisiopatologia , Estudos Retrospectivos , Apneia do Sono Tipo Central/complicações , Apneia do Sono Tipo Central/fisiopatologia , Apneia do Sono Tipo Central/terapia , Traumatismos da Medula Espinal/complicações , Traumatismos da Medula Espinal/patologia , Traumatismos da Medula Espinal/fisiopatologia , Cavidade Torácica/anatomia & histologia , Cavidade Torácica/cirurgia , Toracotomia , Resultado do TratamentoRESUMO
Rats receiving a complete spinal cord transection (ST) at a neonatal stage spontaneously can recover significant stepping ability, whereas minimal recovery is attained in rats transected as adults. In addition, neonatally spinal cord transected rats trained to step more readily improve their locomotor ability. We hypothesized that recovery of stepping in rats receiving a complete spinal cord transection at postnatal day 5 (P5) is attributable to changes in the lumbosacral neural circuitry and not to regeneration of axons across the lesion. As expected, stepping performance measured by several kinematics parameters was significantly better in ST (at P5) trained (treadmill stepping for 8 weeks) than age-matched non-trained spinal rats. Anterograde tracing with biotinylated dextran amine showed an absence of labeling of corticospinal or rubrospinal tract axons below the transection. Retrograde tracing with Fast Blue from the spinal cord below the transection showed no labeled neurons in the somatosensory motor cortex of the hindlimb area, red nucleus, spinal vestibular nucleus, and medullary reticular nucleus. Retrograde labeling transsynaptically via injection of pseudorabies virus (Bartha) into the soleus and tibialis anterior muscles showed no labeling in the same brain nuclei. Furthermore, re-transection of the spinal cord at or rostral to the original transection did not affect stepping ability. Combined, these results clearly indicate that there was no regeneration across the lesion after a complete spinal cord transection in neonatal rats and suggest that this is an important model to understand the higher level of locomotor recovery in rats attributable to lumbosacral mechanisms after receiving a complete ST at a neonatal compared to an adult stage.