Effect of red propolis on hamster cheek pouch angiogenesis in a new sponge implant model
Acta cir. bras
; Acta cir. bras;33(5): 420-430, May 2018. tab, graf
Article
in En
| LILACS
| ID: biblio-949349
Responsible library:
BR1.1
ABSTRACT
Abstract Purpose:
To evaluate the effects of red propolis on cheek pouch angiogenesis in a hamster new model sponge implant.Methods:
Forty eight animals divided into eight groups. (Groups I-IV), the animals were treated for 15 days before and 10 days after sponge implantation. (Groups V-VIII), the animals were treated for 10 days after sponge implantation (GI and GV red propolis 100 mg/kg, GII and GVI celecoxib 20 mg/kg, GIII and GVII 1% gum arabic 5 mL/kg, GIV and GVIII distilled water 5 mL/kg). On the 11th day of implantation, the animals were anesthetized for stereoscopic microscopic imaging and morphometric quantification of angiogenesis (SQAN), followed by histopathological evaluation (H&E).Results:
In the SQAN analysis, no significant difference was found between the groups. However, on histology, propolis was found reduce the population of mastocytes in the qualitative analyses (p = 0,013) in the quantitative analyses to reduce the number of blood vessels (p = 0,007), and increase the macrophage count (p = 0,001).Conclusion:
Red propolis inhibited inflammatory angiogenesis when administered before andcontinuously after sponge implant, and was shown to have immunomodulating effects on inflammatory cells (mastocytes and macrophages) in a new sponge implant hamster model.Key words
Full text:
1
Database:
LILACS
Therapeutic Methods and Therapies TCIM:
Terapias_biologicas
/
Apiterapia
Main subject:
Propolis
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Prostheses and Implants
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Surgical Sponges
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Inflammation
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Neovascularization, Pathologic
Type of study:
Qualitative_research
Language:
En
Journal:
Acta Cir Bras
/
Acta cir. bras
/
Acta cir. bras. (Online)
/
Acta cirúrgica brasileira (Impresso)
Year:
2018
Type:
Article
Affiliation country:
Brazil