Trypanosoma cruzi: analysis of two different strains after piplartine treatment
Braz. j. infect. dis
; Braz. j. infect. dis;22(3): 208-218, May-June 2018. tab, graf
Article
in En
| LILACS
| ID: biblio-974208
Responsible library:
BR1.1
ABSTRACT
ABSTRACT The hemoflagellate protozoan, Trypanosoma cruzi, mainly transmitted by triatomine insects through blood transfusion or from mother-to-child, causes Chagas' disease. This is a serious parasitic disease that occurs in Latin America, with considerable social and economic impact. Nifurtimox and benznidazole, drugs indicated for treating infected persons, are effective in the acute phase, but poorly effective during the chronic phase. Therefore, it is extremely urgent to find innovative chemotherapeutic agents and/or effective vaccines. Since piplartine has several biological activities, including trypanocidal activity, the present study aimed to evaluate it on two T. cruzi strains proteome. Considerable changes in the expression of some important enzymes involved in parasite protection against oxidative stress, such as tryparedoxin peroxidase (TXNPx) and methionine sulfoxide reductase (MSR) was observed in both strains. These findings suggest that blocking the expression of the two enzymes could be potential targets for therapeutic studies.
Key words
Full text:
1
Database:
LILACS
Therapeutic Methods and Therapies TCIM:
Terapias_biologicas
Main subject:
Piperidones
/
Trypanocidal Agents
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Trypanosoma cruzi
/
Plant Extracts
/
Proteins
Type of study:
Evaluation_studies
Language:
En
Journal:
Braz J Infect Dis
/
Braz. j. infect. dis
/
Braz. j. infect. dis. (Online)
/
Brazilian journal of infectious diseases (Impresso)
Year:
2018
Type:
Article
Affiliation country:
Brazil