Epigallocathechin-3 gallate selectively inhibits the PDGF-BB-induced intracellular signaling transduction pathway in vascular smooth muscle cells and inhibits transformation of sis-transfected NIH 3T3 fibroblasts and human glioblastoma cells (A172).

Ahn, H Y; Hadizadeh, K R; Seul, C; Yun, Y P; Vetter, H; Sachinidis, A

Ahn, H Y; Hadizadeh, K R; Seul, C; Yun, Y P; Vetter, H; Sachinidis, A.

Affiliation

Ahn HY; Department of Pharmacology, College of Medicine, Chungbuk National University, Cheongju 361-763, South Korea.

Mol Biol Cell ; 10(4): 1093-104, 1999 Apr.

Article in En | MEDLINE | ID: mdl-10198059

Subject(s)

Antineoplastic Agents/pharmacology; Catechin/analogs & derivatives; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular/physiology; Platelet-Derived Growth Factor/pharmacology; Retroviridae Proteins, Oncogenic/metabolism; Signal Transduction/drug effects; 3T3 Cells; Animals; Aorta; Becaplermin; Brain Neoplasms; Calcium/metabolism; Calcium-Calmodulin-Dependent Protein Kinases/metabolism; Catechin/pharmacology; Cell Transformation, Neoplastic; Cells, Cultured; Glioblastoma; Humans; Kinetics; Mice; Mitogen-Activated Protein Kinase 1/metabolism; Mitogen-Activated Protein Kinase 3; Muscle, Smooth, Vascular/cytology; Muscle, Smooth, Vascular/drug effects; Oncogene Proteins v-sis; Phosphorylation; Phosphotyrosine/metabolism; Proto-Oncogene Proteins c-sis; Rats; Rats, Inbred WKY; Recombinant Proteins/metabolism; Retroviridae Proteins, Oncogenic/genetics; Signal Transduction/physiology; Tea; Transfection; Tumor Cells, Cultured

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Full text: 1 Database: MEDLINE Main subject: Platelet-Derived Growth Factor / Signal Transduction / Catechin / Retroviridae Proteins, Oncogenic / Mitogen-Activated Protein Kinases / Muscle, Smooth, Vascular / Antineoplastic Agents Language: En Journal: Mol Biol Cell Year: 1999 Type: Article Affiliation country: South Korea

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