Cycloprodigiosin hydrochloride obtained from Pseudoalteromonas denitrificans is a potent antimalarial agent.
Biol Pharm Bull
; 22(5): 532-4, 1999 May.
Article
in En
| MEDLINE
| ID: mdl-10375177
ABSTRACT
Cycloprodigiosin hydrochloride (cPrG*HCl) is a stable fluorescent red pigment obtained from the marine bacterium Pseudoalteromonas denitrificans. It was found that the compound was incorporated into Plasmodium falciparum cells upon incubation and exhibited a potent antimalarial activity with the concentration required for 50% of the activity being 11 nM, which is stronger than that of chloroquine, a well-known antimalarial agent. The compound did not affect growth rate of mammalian cells. Antimalarial activity of cPrG*HCl was also observed in vivo. These results indicate that cPrG*HCl is a potent antimalarial drug.
Search on Google
Database:
MEDLINE
Main subject:
Plasmodium falciparum
/
Pyrroles
/
Gram-Negative Aerobic Bacteria
/
Indoles
/
Malaria
/
Antimalarials
Language:
En
Journal:
Biol Pharm Bull
Year:
1999
Type:
Article
Affiliation country:
Japan