The effects of a neutrophil elastase inhibitor (ONO-5046.Na) and neutrophil depletion using a granulotrap (G-1) column on lung reperfusion injury in dogs.

Tomizawa, N; Ohwada, S; Ohya, T; Takeyoshi, I; Ogawa, T; Kawashima, Y; Adachi, M; Morishita, Y

Tomizawa, N; Ohwada, S; Ohya, T; Takeyoshi, I; Ogawa, T; Kawashima, Y; Adachi, M; Morishita, Y.

Affiliation

Tomizawa N; Second Department of Surgery, Gunma University School of Medicine, Maebashi, Japan.

J Heart Lung Transplant ; 18(7): 637-45, 1999 Jul.

Article in En | MEDLINE | ID: mdl-10452339

Subject(s)

Glycine/analogs & derivatives; Leukapheresis/instrumentation; Leukocyte Elastase/antagonists & inhibitors; Lung/blood supply; Reperfusion Injury/therapy; Serine Proteinase Inhibitors/therapeutic use; Sulfonamides/therapeutic use; Animals; Dogs; Drug Evaluation, Preclinical; Glycine/pharmacology; Glycine/therapeutic use; Hemodynamics/drug effects; Leukapheresis/methods; Lung/pathology; Neutrophils; Organ Size/drug effects; Random Allocation; Recombinant Proteins/pharmacology; Recombinant Proteins/therapeutic use; Reperfusion Injury/blood; Reperfusion Injury/pathology; Reperfusion Injury/physiopathology; Serine Proteinase Inhibitors/pharmacology; Sulfonamides/pharmacology; Time Factors

Search on Google

Add to My VHL

XML

PubMed Links

Database: MEDLINE Main subject: Sulfonamides / Reperfusion Injury / Serine Proteinase Inhibitors / Leukapheresis / Leukocyte Elastase / Glycine / Lung Type of study: Prognostic_studies Language: En Journal: J Heart Lung Transplant Year: 1999 Type: Article Affiliation country: Japan

Search on Google

Add to My VHL

XML

PubMed Links