Evaluation of the anti-diabetic property of Morinda lucida leaves in streptozotocin-diabetic rats.
J Pharm Pharmacol
; 51(11): 1321-4, 1999 Nov.
Article
in En
| MEDLINE
| ID: mdl-10632091
ABSTRACT
The hypoglycaemic and anti-hyperglycaemic activities of a methanol extract of Morinda lucida Benth. (Rubiaceae) leaves were studied in normal and streptozotocin-diabetic rats. In normal rats, the extract demonstrated a significant (P < 0.05) and dose-dependent hypoglycaemic activity within 4 h after oral administration. The plasma glucose level of 400 mg kg(-1) of the extract at 4 h was 42.5 +/- 0.4 mg/100 mL (control 67.4 +/- 1.2 mg/100 mL). After 12 h, the plasma glucose level of rats administered 50, 100, 200 or 400 mg kg(-1) extract fell to 51.9 +/- 1.2, 47.3 +/- 0.8, 43.1 +/- 0.4 and 40.0 +/- 0.5 mg/100 mL, respectively. In hyperglycaemic rats, the extract produced a significant (P < 0.05) anti-diabetic effect from day 3 after oral administration, with 400 mg kg(-1) extract-treated animals having a plasma glucose level of 248.7 +/- 5.3 mg/100 mL compared with glibenclamide (10 mg kg(-1))-treated animals with a plasma glucose level of 251.5 +/- 5.8 mg/100 mL. These results suggest that the leaves of Morinda lucida have a strong glucose lowering property when administered to streptozotocin-treated rats.
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Database:
MEDLINE
Therapeutic Methods and Therapies TCIM:
Terapias_biologicas
/
Plantas_medicinales
Main subject:
Plants, Medicinal
/
Diabetes Mellitus, Experimental
/
Hypoglycemic Agents
Language:
En
Journal:
J Pharm Pharmacol
Year:
1999
Type:
Article
Affiliation country:
Nigeria