The protein kinase inhibitor fasudil protects against ischemic myocardial injury induced by endothelin-1 in the rabbit.

Yamamoto, Y; Ikegaki, I; Sasaki, Y; Uchida, T

Yamamoto, Y; Ikegaki, I; Sasaki, Y; Uchida, T.

Affiliation

Yamamoto Y; Institute for Life Science Research, Asahi Chemical Industry, Co., Ltd., Fuji, Shizuoka, Japan.

J Cardiovasc Pharmacol ; 35(2): 203-11, 2000 Feb.

Article in En | MEDLINE | ID: mdl-10672851

Subject(s)

1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine/analogs & derivatives; Endothelin-1/antagonists & inhibitors; Enzyme Inhibitors/therapeutic use; Myocardial Ischemia/prevention & control; Papillary Muscles/drug effects; 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine/pharmacology; Animals; Cell Movement/drug effects; Diltiazem/pharmacology; Electrocardiography/drug effects; Heart Ventricles/drug effects; Heart Ventricles/pathology; Macrophages/physiology; Male; Microscopy; Myocardial Ischemia/pathology; Necrosis; Neutrophils/physiology; Nicorandil/pharmacology; Nifedipine/pharmacology; Papillary Muscles/ultrastructure; Rabbits; Random Allocation; Vasodilator Agents/pharmacology

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Database: MEDLINE Therapeutic Methods and Therapies TCIM: Terapias_biologicas / Aromoterapia Main subject: Papillary Muscles / Myocardial Ischemia / 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine / Endothelin-1 / Enzyme Inhibitors Language: En Journal: J Cardiovasc Pharmacol Year: 2000 Type: Article Affiliation country: Japan

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