Subcutaneous administration of superoxide dismutase entrapped in long circulating liposomes: in vivo fate and therapeutic activity in an inflammation model.

Corvo, M L; Boerman, O C; Oyen, W J; Jorge, J C; Cruz, M E; Crommelin, D J; Storm, G

Corvo, M L; Boerman, O C; Oyen, W J; Jorge, J C; Cruz, M E; Crommelin, D J; Storm, G.

Affiliation

Corvo ML; Unidade de Novas Formas de Agentes Bioactivos - DB - IBQTA - INETI, Lisboa, Portugal. luisa.corvo@ibqta.ineti.pt

Pharm Res ; 17(5): 600-6, 2000 May.

Article in En | MEDLINE | ID: mdl-10888313

Subject(s)

Inflammation/drug therapy; Superoxide Dismutase/administration & dosage; Animals; Drug Carriers; Drug Compounding; Drug Stability; Freund's Adjuvant; Inflammation/chemically induced; Inflammation/pathology; Injections, Subcutaneous; Liposomes; Male; Mycobacterium/immunology; Particle Size; Polyethylene Glycols; Rats; Rats, Wistar; Superoxide Dismutase/pharmacokinetics; Superoxide Dismutase/therapeutic use; Tissue Distribution

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Database: MEDLINE Main subject: Superoxide Dismutase / Inflammation Type of study: Prognostic_studies Language: En Journal: Pharm Res Year: 2000 Type: Article Affiliation country: Portugal

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