Beneficial effects of tempol, a membrane-permeable radical scavenger, in a rodent model of splanchnic artery occlusion and reperfusion.

Cuzzocrea, S; McDonald, M C; Mazzon, E; Filipe, H M; Costantino, G; Caputi, A P; Thiemermann, C

Cuzzocrea, S; McDonald, M C; Mazzon, E; Filipe, H M; Costantino, G; Caputi, A P; Thiemermann, C.

Affiliation

Cuzzocrea S; Institute of Pharmacology, School of Medicine, University of Messina, Italy.

Shock ; 14(2): 150-6, 2000 Aug.

Article in En | MEDLINE | ID: mdl-10947159

Subject(s)

Arterial Occlusive Diseases/drug therapy; Cyclic N-Oxides/therapeutic use; Free Radical Scavengers/therapeutic use; Ileum/blood supply; Reperfusion Injury/prevention & control; Splanchnic Circulation; Animals; Celiac Artery; Cell Membrane Permeability; Constriction; Cyclic N-Oxides/pharmacokinetics; Drug Evaluation, Preclinical; Enzyme Induction; Free Radical Scavengers/pharmacokinetics; Ileum/chemistry; Ileum/pathology; Intercellular Adhesion Molecule-1/analysis; Lipid Peroxidation; Male; Malondialdehyde/analysis; Mesenteric Artery, Superior; Nitrates/metabolism; P-Selectin/analysis; Peroxidase/metabolism; Poly(ADP-ribose) Polymerases/biosynthesis; Rats; Rats, Sprague-Dawley; Reperfusion Injury/etiology; Spin Labels

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Database: MEDLINE Main subject: Arterial Occlusive Diseases / Splanchnic Circulation / Reperfusion Injury / Free Radical Scavengers / Cyclic N-Oxides / Ileum Type of study: Etiology_studies Language: En Journal: Shock Year: 2000 Type: Article Affiliation country: Italy

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