Effects of sigma(1) receptor ligand, MS-377 on apomorphine- or phencyclidine-induced disruption of prepulse inhibition of acoustic startle in rats.
Eur J Pharmacol
; 402(3): 251-4, 2000 Aug 25.
Article
in En
| MEDLINE
| ID: mdl-10958892
ABSTRACT
To evaluate the antipsychotic property of a sigma(1) receptor ligand, (R)-(+)-1-(4-chlorophenyl)-3-¿4-(2-methoxyethyl)piperazin-1-yl¿ methyl-2-pyrrolidinone-L-tartrate (MS-377), an antagonistic effect of MS-377 on the disruption of prepulse inhibition (PPI) of the acoustic startle by apomorphine or phencyclidine (PCP) was investigated in rats. MS-377 antagonized the PCP-induced disruption of PPI. The ED(50) value of MS-377 for this effect was 0.66 mg/kg. In contrast, apomorphine-induced disruption of PPI was not attenuated by MS-377. These data indicate that the PCP-induced disruption of PPI in rats would be, at least partially, mediated by sigma receptors and MS-377 could be a novel anti-psychotic agent with clinical efficacy for the sensorimotor-gating deficit in schizophrenia.
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Database:
MEDLINE
Main subject:
Phencyclidine
/
Piperazines
/
Pyrrolidines
/
Reflex, Startle
/
Tartrates
/
Antipsychotic Agents
/
Apomorphine
/
Receptors, sigma
/
Excitatory Amino Acid Antagonists
/
Dopamine Agonists
Language:
En
Journal:
Eur J Pharmacol
Year:
2000
Type:
Article
Affiliation country:
Japan