Interferon beta-1a downregulates TNFalpha-induced intercellular adhesion molecule 1 expression on brain microvascular endothelial cells through a tyrosine kinase-dependent pathway.

Defazio, G; Livrea, P; Giorelli, M; Martino, D; Roselli, F; Ricchiuti, F; Trojano, M

Defazio, G; Livrea, P; Giorelli, M; Martino, D; Roselli, F; Ricchiuti, F; Trojano, M.

Affiliation

Defazio G; Department of Neurologic and Psychiatric Sciences, University of Bari, I-70124, Bari, Italy. gdefazio@neurol.uniba.it

Brain Res ; 881(2): 227-30, 2000 Oct 27.

Article in En | MEDLINE | ID: mdl-11036165

Subject(s)

Adjuvants, Immunologic/pharmacology; Blood-Brain Barrier/drug effects; Endothelium, Vascular/drug effects; Intercellular Adhesion Molecule-1/drug effects; Interferon-beta/pharmacology; Adjuvants, Immunologic/therapeutic use; Animals; Blood-Brain Barrier/physiology; Cells, Cultured; Down-Regulation; Endothelium, Vascular/metabolism; Enzyme Inhibitors/pharmacology; Genistein/pharmacology; Humans; Intercellular Adhesion Molecule-1/metabolism; Interferon beta-1a; Interferon-beta/therapeutic use; Male; Multiple Sclerosis/drug therapy; Multiple Sclerosis/metabolism; Protein-Tyrosine Kinases/drug effects; Protein-Tyrosine Kinases/metabolism; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha/pharmacology

Search on Google

Add to My VHL

XML

PubMed Links

Database: MEDLINE Main subject: Endothelium, Vascular / Blood-Brain Barrier / Adjuvants, Immunologic / Interferon-beta / Intercellular Adhesion Molecule-1 Language: En Journal: Brain Res Year: 2000 Type: Article Affiliation country: Italy

Search on Google

Add to My VHL

XML

PubMed Links