A novel adapter protein employs a phosphotyrosine binding domain and exceptionally basic N-terminal domains to capture and localize an atypical protein kinase C: characterization of Caenorhabditis elegans C kinase adapter 1, a protein that avidly binds protein kinase C3.

Zhang, L; Wu, S L; Rubin, C S

Zhang, L; Wu, S L; Rubin, C S.

Affiliation

Zhang L; Department of Molecular Pharmacology, Atran Laboratories, Albert Einstein College of Medicine, Bronx, New York 10461, USA.

J Biol Chem ; 276(13): 10463-75, 2001 Mar 30.

Article in En | MEDLINE | ID: mdl-11134024

Subject(s)

Adaptor Proteins, Signal Transducing; Caenorhabditis elegans Proteins; Carrier Proteins/metabolism; Phosphotyrosine/metabolism; Protein Kinase C/chemistry; Amino Acid Sequence; Amino Acids/chemistry; Animals; Animals, Genetically Modified; Base Sequence; Binding Sites; Blotting, Northern; Blotting, Western; Caenorhabditis elegans/chemistry; Caenorhabditis elegans/genetics; Caenorhabditis elegans/metabolism; Carrier Proteins/chemistry; Carrier Proteins/genetics; Cell Line; Cell Membrane/metabolism; Cells, Cultured; Codon; DNA, Complementary/metabolism; Dogs; Electrophoresis, Polyacrylamide Gel; Gene Deletion; Gene Library; Microscopy, Fluorescence; Molecular Sequence Data; Mutagenesis, Site-Directed; Phenylalanine/chemistry; Phosphorylation; Precipitin Tests; Promoter Regions, Genetic; Protein Binding; Protein Biosynthesis; Protein Isoforms; Protein Kinase C/metabolism; Protein Structure, Tertiary; RNA, Messenger/metabolism; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Swine; Transcription, Genetic; Transfection; Tumor Cells, Cultured; Two-Hybrid System Techniques

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Database: MEDLINE Main subject: Protein Kinase C / Carrier Proteins / Phosphotyrosine / Caenorhabditis elegans Proteins / Adaptor Proteins, Signal Transducing Language: En Journal: J Biol Chem Year: 2001 Type: Article Affiliation country: United States

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