Single administration of thrombopoietin to lethally irradiated mice prevents infectious and thrombotic events leading to mortality.

Mouthon, M A; Gaugler, M H; Van der Meeren, A; Vandamme, M; Gourmelon, P; Wagemaker, G

Mouthon, M A; Gaugler, M H; Van der Meeren, A; Vandamme, M; Gourmelon, P; Wagemaker, G.

Affiliation

Mouthon MA; Institut de Protection et de Sûreté Nucléaire, IPSN, Fontenay-aux-Roses Cedex, France. marc-andre.mouthon@ipsn.fr

Exp Hematol ; 29(1): 30-40, 2001 Jan.

Article in En | MEDLINE | ID: mdl-11164103

Subject(s)

Bacterial Infections/prevention & control; Radiation Injuries, Experimental/drug therapy; Thrombopoietin/therapeutic use; Thrombosis/prevention & control; Animals; Bacterial Infections/etiology; Biomarkers; Blood Coagulation Disorders/etiology; Bone Marrow/drug effects; Bone Marrow Diseases/complications; Bone Marrow Diseases/etiology; Disease Susceptibility; Drug Evaluation, Preclinical; Endotoxemia/etiology; Endotoxemia/prevention & control; Fibrinogen/analysis; Fibrinogen/biosynthesis; Fibrinogen/genetics; Fibrinolysis/drug effects; Hemorrhage/etiology; Hemorrhage/prevention & control; Immunologic Deficiency Syndromes/etiology; Leukocyte Count; Male; Mice; Mice, Inbred C57BL; Neutrophils; Platelet Activation/drug effects; Platelet Count; RNA, Messenger/biosynthesis; Radiation Injuries, Experimental/blood; Radiation Injuries, Experimental/complications; Radiation Injuries, Experimental/immunology; Recombinant Proteins/pharmacology; Recombinant Proteins/therapeutic use; Thrombopoietin/pharmacology; Thrombosis/etiology; Whole-Body Irradiation/adverse effects

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Database: MEDLINE Main subject: Radiation Injuries, Experimental / Thrombopoietin / Thrombosis / Bacterial Infections Type of study: Etiology_studies / Prognostic_studies Language: En Journal: Exp Hematol Year: 2001 Type: Article Affiliation country: France

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