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Glomangiopericytoma causing oncogenic osteomalacia. A case report with immunohistochemical analysis.
Sakamoto, A; Oda, Y; Nagayoshi, Y; Iwakiri, K; Tamiya, S; Iwamoto, Y; Tsuneyoshi, M.
Affiliation
  • Sakamoto A; Second Department of Pathology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Arch Orthop Trauma Surg ; 121(1-2): 104-8, 2001.
Article in En | MEDLINE | ID: mdl-11195105
A 47-year-old woman suffered from gait disturbance due to back pain and muscle weakness. Laboratory data showed serum hypophosphatemia, elevated alkaline phosphatase, and a normal level of ionized calcium. Radiological examinations revealed multiple pathologic fractures in the ribs and pubic rami. She had had no episode of familial or any other notable disorder, and so she was initially treated with medication for adult-onset osteomalacia. However, 19 years later (when she was 66 years old), she noticed a soft-tissue tumor in her buttock. The tumor was excised. The histological features were those of glomangiopericytoma characterized by both glomus tumor-like and hemangiopericytoma-like structures. After removal of the tumor, her symptoms disappeared immediately. Laboratory data normalized 8 months later. To our knowledge, this is the first report of oncogenic osteomalacia caused by glomangiopericytoma.
Subject(s)
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Database: MEDLINE Main subject: Osteomalacia / Pubic Bone / Rib Fractures / Soft Tissue Neoplasms / Buttocks / Glomus Tumor / Fractures, Spontaneous / Hemangiopericytoma Type of study: Diagnostic_studies / Etiology_studies Language: En Journal: Arch Orthop Trauma Surg Year: 2001 Type: Article Affiliation country: Japan
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Database: MEDLINE Main subject: Osteomalacia / Pubic Bone / Rib Fractures / Soft Tissue Neoplasms / Buttocks / Glomus Tumor / Fractures, Spontaneous / Hemangiopericytoma Type of study: Diagnostic_studies / Etiology_studies Language: En Journal: Arch Orthop Trauma Surg Year: 2001 Type: Article Affiliation country: Japan