Three for T: molecular analysis of the low voltage-activated calcium channel family.
Cell Mol Life Sci
; 56(7-8): 660-9, 1999 Nov 15.
Article
in En
| MEDLINE
| ID: mdl-11212313
ABSTRACT
Despite the wealth of information on voltage-gated calcium channels, little is known about low voltage-activated, T-type channels. The ability of the antihypertensive drug mibefradil to selectively block T-type channels has generated much interest in their structure, physiology and pharmacology. This review covers the cloning of a new family of calcium channels, their putative structure, the electrophysiological evidence that demonstrated that these complementary DNAs encoded low voltage-activated, T-type channels, the tissue expression of these genes, and concludes with a discussion of their possible physiological roles.
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Database:
MEDLINE
Main subject:
Ion Channel Gating
/
Calcium Channels, T-Type
Language:
En
Journal:
Cell Mol Life Sci
Year:
1999
Type:
Article
Affiliation country:
United States