Mutation of conserved aspartates affect maturation of presenilin 1 and presenilin 2 complexes.

Yu, G; Chen, F; Nishimura, M; Steiner, H; Tandon, A; Kawarai, T; Arawaka, S; Supala, A; Song, Y Q; Rogaeva, E; Holmes, E; Zhang, D M; Milman, P; Fraser, P; Haass, C; St George-Hyslop, P

Yu, G; Chen, F; Nishimura, M; Steiner, H; Tandon, A; Kawarai, T; Arawaka, S; Supala, A; Song, Y Q; Rogaeva, E; Holmes, E; Zhang, D M; Milman, P; Fraser, P; Haass, C; St George-Hyslop, P.

Affiliation

Yu G; Centre for Research in Neurodegenerative Diseases, Department of Medical, Biophysics, University of Toronto, Ontario, Canada.

Acta Neurol Scand Suppl ; 176: 6-11, 2000.

Article in En | MEDLINE | ID: mdl-11261807

Subject(s)

Alzheimer Disease/physiopathology; Aspartic Acid/metabolism; Membrane Proteins/genetics; Point Mutation; Amyloid Precursor Protein Secretases; Amyloid beta-Peptides/metabolism; Animals; Aspartic Acid/analogs & derivatives; Aspartic Acid/genetics; Aspartic Acid Endopeptidases; Cell Culture Techniques; Cell Membrane; DNA, Complementary/genetics; Endopeptidases/metabolism; Gene Expression Regulation; Humans; Membrane Proteins/metabolism; Mice; Presenilin-1; Presenilin-2; Protein Conformation

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Database: MEDLINE Main subject: Point Mutation / Aspartic Acid / Alzheimer Disease / Membrane Proteins Language: En Journal: Acta Neurol Scand Suppl Year: 2000 Type: Article Affiliation country: Canada

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