Structures of withanosides I, II, III, IV, V, VI, and VII, new withanolide glycosides, from the roots of Indian Withania somnifera DUNAL. and inhibitory activity for tachyphylaxis to clonidine in isolated guinea-pig ileum.

Matsuda, H; Murakami, T; Kishi, A; Yoshikawa, M

Matsuda, H; Murakami, T; Kishi, A; Yoshikawa, M.

Affiliation

Matsuda H; Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto 607-8412, Kyoto, Japan

Bioorg Med Chem ; 9(6): 1499-507, 2001 Jun.

Article in En | MEDLINE | ID: mdl-11408168

Subject(s)

Clonidine/pharmacology; Disaccharides/chemistry; Disaccharides/pharmacology; Ergosterol/analogs & derivatives; Ergosterol/chemistry; Ergosterol/pharmacology; Monosaccharides/chemistry; Monosaccharides/pharmacology; Plants, Medicinal/chemistry; Tachyphylaxis; Adrenergic alpha-Agonists/pharmacology; Animals; Disaccharides/isolation & purification; Drug Evaluation, Preclinical; Ergosterol/isolation & purification; Female; Guinea Pigs; Ileum/drug effects; Ileum/physiology; In Vitro Techniques; India; Lactones/chemistry; Molecular Structure; Monosaccharides/isolation & purification; Plant Roots/chemistry; Solanaceae/chemistry; Withanolides

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Database: MEDLINE Therapeutic Methods and Therapies TCIM: Terapias_biologicas Main subject: Plants, Medicinal / Tachyphylaxis / Clonidine / Disaccharides / Ergosterol / Monosaccharides Country/Region as subject: Asia Language: En Journal: Bioorg Med Chem Year: 2001 Type: Article Affiliation country: Japan

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