Evaluation of the BBMEC model for screening the CNS permeability of drugs.

Otis, K W; Avery, M L; Broward-Partin, S M; Hansen, D K; Behlow, H W; Scott, D O; Thompson, T N

Otis, K W; Avery, M L; Broward-Partin, S M; Hansen, D K; Behlow, H W; Scott, D O; Thompson, T N.

Affiliation

Otis KW; Quintiles Inc., PO Box 9708, Kansas City, MO 64134, USA. tom.thompson@quintiles.com

J Pharmacol Toxicol Methods ; 45(1): 71-7, 2001.

Article in En | MEDLINE | ID: mdl-11489667

Subject(s)

Blood-Brain Barrier; Brain/blood supply; Drug Evaluation, Preclinical/methods; Endothelium, Vascular/metabolism; Animals; Antineoplastic Agents, Phytogenic/pharmacokinetics; Biological Transport; Caffeine/pharmacokinetics; Cattle; Central Nervous System Agents/pharmacokinetics; Drug Combinations; Mannitol/pharmacokinetics; Microdialysis; Models, Biological; Permeability; Vinblastine/pharmacokinetics

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Database: MEDLINE Main subject: Brain / Endothelium, Vascular / Blood-Brain Barrier / Drug Evaluation, Preclinical Type of study: Diagnostic_studies / Screening_studies Language: En Journal: J Pharmacol Toxicol Methods Year: 2001 Type: Article Affiliation country: United States

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