Targeting Janus kinase 3 to attenuate the severity of acute graft-versus-host disease across the major histocompatibility barrier in mice.

Cetkovic-Cvrlje, M; Roers, B A; Waurzyniak, B; Liu, X P; Uckun, F M

Cetkovic-Cvrlje, M; Roers, B A; Waurzyniak, B; Liu, X P; Uckun, F M.

Affiliation

Cetkovic-Cvrlje M; Experimental BMT Program, Parker Hughes Cancer Center, and the Department of Immunology, Parker Hughes Institute, St Paul, MN 55113, USA.

Blood ; 98(5): 1607-13, 2001 Sep 01.

Article in En | MEDLINE | ID: mdl-11520814

Subject(s)

Bone Marrow Transplantation/adverse effects; Enzyme Inhibitors/therapeutic use; Graft vs Host Disease/therapy; H-2 Antigens/immunology; Immunosuppressive Agents/therapeutic use; Protein-Tyrosine Kinases/antagonists & inhibitors; Quinazolines/therapeutic use; Acute Disease; Animals; Cell Transplantation/adverse effects; Drug Evaluation, Preclinical; Drug Therapy, Combination; Enzyme Inhibitors/administration & dosage; Graft vs Host Disease/immunology; Immunosuppressive Agents/administration & dosage; Janus Kinase 3; Lymphocyte Activation/drug effects; Lymphocyte Culture Test, Mixed; Male; Methotrexate/administration & dosage; Methotrexate/therapeutic use; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Phytohemagglutinins/pharmacology; Quinazolines/administration & dosage; Radiation Chimera; Signal Transduction/drug effects; Spleen/cytology; T-Lymphocytes, Cytotoxic/drug effects; T-Lymphocytes, Cytotoxic/enzymology; Whole-Body Irradiation

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Database: MEDLINE Main subject: Quinazolines / Protein-Tyrosine Kinases / H-2 Antigens / Bone Marrow Transplantation / Enzyme Inhibitors / Graft vs Host Disease / Immunosuppressive Agents Language: En Journal: Blood Year: 2001 Type: Article Affiliation country: United States

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