Simple isoquinoline and benzylisoquinoline alkaloids as potential antimicrobial, antimalarial, cytotoxic, and anti-HIV agents.

Iwasa, K; Moriyasu, M; Tachibana, Y; Kim, H S; Wataya, Y; Wiegrebe, W; Bastow, K F; Cosentino, L M; Kozuka, M; Lee, K H

Iwasa, K; Moriyasu, M; Tachibana, Y; Kim, H S; Wataya, Y; Wiegrebe, W; Bastow, K F; Cosentino, L M; Kozuka, M; Lee, K H.

Affiliation

Iwasa K; Kobe Pharmaceutical University, 4-19-1Motoyamakita, Higashinada-ku, 658-8558, Kobe, Japan.

Bioorg Med Chem ; 9(11): 2871-84, 2001 Nov.

Article in En | MEDLINE | ID: mdl-11597468

Subject(s)

Anti-Infective Agents/chemical synthesis; Anti-Infective Agents/pharmacology; Antineoplastic Agents/chemical synthesis; Antineoplastic Agents/pharmacology; Isoquinolines/pharmacology; Alkaloids/chemical synthesis; Alkaloids/chemistry; Alkaloids/pharmacology; Animals; Anti-Bacterial Agents; Anti-HIV Agents/chemical synthesis; Anti-HIV Agents/chemistry; Anti-HIV Agents/pharmacology; Anti-Infective Agents/chemistry; Antimalarials/chemical synthesis; Antimalarials/chemistry; Antimalarials/pharmacology; Antineoplastic Agents/chemistry; Candida albicans/drug effects; Cell Division/drug effects; Crystallization; Drug Evaluation, Preclinical; Gram-Negative Bacteria/drug effects; Gram-Positive Bacteria/drug effects; HIV-1/drug effects; Humans; Isoquinolines/chemical synthesis; Isoquinolines/chemistry; Magnetic Resonance Spectroscopy; Mice; Microbial Sensitivity Tests; Plasmodium falciparum/drug effects; Structure-Activity Relationship; Tumor Cells, Cultured/drug effects

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Database: MEDLINE Main subject: Isoquinolines / Anti-Infective Agents / Antineoplastic Agents Language: En Journal: Bioorg Med Chem Year: 2001 Type: Article Affiliation country: Japan

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