Synthesis and biological evaluation of a series of novel N- or O-fluoroalkyl derivatives of tropane: potential positron emission tomography (PET) imaging agents for the dopamine transporter.

Gu, X H; Zong, R; Kula, N S; Baldessarini, R J; Neumeyer, J L

Gu, X H; Zong, R; Kula, N S; Baldessarini, R J; Neumeyer, J L.

Affiliation

Gu XH; Medicinal Chemistry Laboratory, Alcohol and Drug Abuse Research Center, Belmont, MA 02478-9106, USA.

Bioorg Med Chem Lett ; 11(23): 3049-53, 2001 Dec 03.

Article in En | MEDLINE | ID: mdl-11714608

Subject(s)

Cocaine/chemistry; Cocaine/metabolism; Iodine Radioisotopes/chemistry; Iodine Radioisotopes/metabolism; Membrane Transport Proteins/analysis; Nerve Tissue Proteins; Tomography, Emission-Computed/methods; Tropanes/chemistry; Animals; Binding, Competitive; Carrier Proteins/analysis; Carrier Proteins/metabolism; Cocaine/analogs & derivatives; Dopamine Plasma Membrane Transport Proteins; Drug Evaluation, Preclinical; Membrane Glycoproteins/analysis; Membrane Glycoproteins/metabolism; Membrane Transport Proteins/metabolism; Norepinephrine Plasma Membrane Transport Proteins; Radioligand Assay; Rats; Serotonin Plasma Membrane Transport Proteins; Structure-Activity Relationship; Symporters/analysis; Symporters/metabolism

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Database: MEDLINE Main subject: Membrane Transport Proteins / Tropanes / Tomography, Emission-Computed / Cocaine / Iodine Radioisotopes / Nerve Tissue Proteins Language: En Journal: Bioorg Med Chem Lett Year: 2001 Type: Article Affiliation country: United States

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