Diffusion-weighted MR imaging of Carmofur-induced leukoencephalopathy.
Eur Radiol
; 11(12): 2602-6, 2001.
Article
in En
| MEDLINE
| ID: mdl-11734966
ABSTRACT
Carmofur (1-hexylcarbamyl-5-fluorouracil), a derivative of 5-fluorouracil (5-FU), has been widely used in Japan as a postoperative adjuvant chemotherapy agent for colorectal and breast cancer. Periventricular hyperintensity on T2-weighted MR images in carmofur-induced leukoencephalopathy confront the physician with a broad range of differential diagnoses. We describe two cases of carmofur-induced leukoencephalopathy in which diffusion-weighted MR imaging revealed periventricular hyperintensity. We compared their findings with those of age-related periventricular hyperintensity in five patients and found discrepancies in signal intensity of periventricular areas. Our results suggest that diffusion-weighted MR imaging may be useful to differentiate carmofur-induced leukoencephalopathy from age-related periventricular hyperintensity.
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Database:
MEDLINE
Main subject:
Brain Diseases
/
Magnetic Resonance Imaging
/
Image Enhancement
/
Encephalomalacia
/
Fluorouracil
/
Antineoplastic Agents
Type of study:
Diagnostic_studies
Language:
En
Journal:
Eur Radiol
Year:
2001
Type:
Article
Affiliation country:
Japan