Testicular germ cell tumor with rhabdomyosarcoma successfully treated by disease-adapted chemotherapy including high-dose chemotherapy: case report and review of the literature.
Bone Marrow Transplant
; 28(8): 787-9, 2001 Oct.
Article
in En
| MEDLINE
| ID: mdl-11781632
ABSTRACT
Treatment and prognosis have not been well characterized in germ cell tumors (GCT) with a malignant nongerm cell component. Patients with a mediastinal tumor, neural or rhabdomyosarcomatous differentiation and distant metastases have the poorest prognosis. We report a rare case of mixed GCT composed of seminoma, teratoma and rhabdomyosarcoma with the rhabdomyosarcomatous component metastasized into the liver and bone marrow (BM) causing hypercalcemia. The patient was treated with differentiation-tailored chemotherapy (CHT) including a disease-adapted high-dose (HD) CHT regimen with purified autologous PBSCT (APBSCT) and pamidronate. To date, remission has lasted for 4 years. Tumor-adapted CHT including HD-CHT with APBSCT can induce long term remissions in high-risk patients with transformed GCT. A review of the literature is given.
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Database:
MEDLINE
Main subject:
Rhabdomyosarcoma
/
Teratoma
/
Testicular Neoplasms
/
Antineoplastic Combined Chemotherapy Protocols
/
Seminoma
/
Hematopoietic Stem Cell Transplantation
/
Neoplasms, Multiple Primary
Type of study:
Etiology_studies
/
Prognostic_studies
Language:
En
Journal:
Bone Marrow Transplant
Year:
2001
Type:
Article
Affiliation country:
Germany