Inhibition of tumour cell growth by hyperforin, a novel anticancer drug from St. John's wort that acts by induction of apoptosis.

Schempp, Christoph M; Kirkin, Vladimir; Simon-Haarhaus, Birgit; Kersten, Astrid; Kiss, Judit; Termeer, Christian C; Gilb, Bernhard; Kaufmann, Thomas; Borner, Christoph; Sleeman, Jonathan P; Simon, Jan C

Schempp, Christoph M; Kirkin, Vladimir; Simon-Haarhaus, Birgit; Kersten, Astrid; Kiss, Judit; Termeer, Christian C; Gilb, Bernhard; Kaufmann, Thomas; Borner, Christoph; Sleeman, Jonathan P; Simon, Jan C.

Affiliation

Schempp CM; Department of Dermatology, University of Freiburg, Hauptstrasse 7, D-79104 Freiburg, Germany. schempp@haut.ukl.uni-freiburg.de

Oncogene ; 21(8): 1242-50, 2002 Feb 14.

Article in En | MEDLINE | ID: mdl-11850844

Subject(s)

Antineoplastic Agents/pharmacology; Apoptosis/drug effects; Hypericum/chemistry; Neoplasms/pathology; Terpenes/pharmacology; Animals; Antineoplastic Agents/chemistry; Bridged Bicyclo Compounds; Caspases/metabolism; Cell Division/drug effects; Cytochrome c Group/metabolism; Dose-Response Relationship, Drug; Enzyme Activation/drug effects; Female; Humans; Intracellular Membranes/drug effects; Intracellular Membranes/metabolism; Microscopy, Electron; Mitochondria/drug effects; Mitochondria/metabolism; Mitochondria/ultrastructure; Neoplasms/enzymology; Neoplasms/ultrastructure; Phloroglucinol/analogs & derivatives; Rats; Staurosporine/pharmacology; Terpenes/chemistry; Time Factors; Tumor Cells, Cultured

Search on Google

Add to My VHL

XML

PubMed Links

Database: MEDLINE Complementary Medicines: Homeopatia Main subject: Terpenes / Apoptosis / Hypericum / Neoplasms / Antineoplastic Agents Language: En Journal: Oncogene Year: 2002 Type: Article Affiliation country: Germany

Search on Google

Add to My VHL

XML

PubMed Links