Drugs elevating extracellular adenosine promote regeneration of haematopoietic progenitor cells in severely myelosuppressed mice: their comparison and joint effects with the granulocyte colony-stimulating factor.

Hofer, Michal; Pospísil, Milan; Znojil, Vladimír; Vacek, Antonín; Weiterova, Lenka; Holá, Jirina; Vácha, Jirí

Hofer, Michal; Pospísil, Milan; Znojil, Vladimír; Vacek, Antonín; Weiterova, Lenka; Holá, Jirina; Vácha, Jirí.

Affiliation

Hofer M; Institute of Biophysics, Institute of Sciences of the Czech Republic, Královopolská 135, CZ-612 Brno, Czech Republic. hofer@ibp.cz

Eur J Haematol ; 68(1): 4-11, 2002 Jan.

Article in En | MEDLINE | ID: mdl-11995629

Subject(s)

Adenosine Monophosphate/therapeutic use; Adenosine/metabolism; Bone Marrow/drug effects; Dipyridamole/therapeutic use; Granulocyte Colony-Stimulating Factor/therapeutic use; Hematopoietic Stem Cells/pathology; Pancytopenia/drug therapy; Prodrugs/therapeutic use; Adenosine Monophosphate/pharmacology; Animals; Blood Cell Count; Bone Marrow/pathology; Bone Marrow/radiation effects; Carboplatin/toxicity; Dipyridamole/pharmacology; Drug Evaluation, Preclinical; Drug Synergism; Erythroid Precursor Cells/pathology; Extracellular Space/metabolism; Granulocyte Colony-Stimulating Factor/pharmacology; Lymphocytes/pathology; Macrophages/pathology; Male; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Pancytopenia/etiology; Pancytopenia/metabolism; Pancytopenia/pathology; Prodrugs/pharmacology; Whole-Body Irradiation/adverse effects

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Database: MEDLINE Main subject: Pancytopenia / Bone Marrow / Hematopoietic Stem Cells / Prodrugs / Adenosine / Adenosine Monophosphate / Granulocyte Colony-Stimulating Factor / Dipyridamole Type of study: Etiology_studies Language: En Journal: Eur J Haematol Year: 2002 Type: Article Affiliation country: Czech Republic

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