Natural products inhibiting Candida albicans secreted aspartic proteases from Lycopodium cernuum.

Zhang, Zhizhen; ElSohly, Hala N; Jacob, Melissa R; Pasco, David S; Walker, Larry A; Clark, Alice M

Zhang, Zhizhen; ElSohly, Hala N; Jacob, Melissa R; Pasco, David S; Walker, Larry A; Clark, Alice M.

Affiliation

Zhang Z; National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, Department of Pharmacognosy, The University of Mississippi, University, Mississippi 38677, USA.

J Nat Prod ; 65(7): 979-85, 2002 Jul.

Article in En | MEDLINE | ID: mdl-12141856

Subject(s)

Antifungal Agents/isolation & purification; Aspartic Acid Endopeptidases/antagonists & inhibitors; Candida albicans/drug effects; Enzyme Inhibitors/isolation & purification; Lycopodiaceae/chemistry; Plants, Medicinal/chemistry; Protease Inhibitors/isolation & purification; Triterpenes/isolation & purification; Acetylation; Antifungal Agents/chemistry; Antifungal Agents/pharmacology; Chromatography, High Pressure Liquid; Enzyme Inhibitors/chemistry; Enzyme Inhibitors/pharmacology; Hydrolysis; Inhibitory Concentration 50; Molecular Conformation; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Peru; Protease Inhibitors/chemistry; Protease Inhibitors/pharmacology; Spectroscopy, Fourier Transform Infrared; Structure-Activity Relationship; Triterpenes/chemistry; Triterpenes/pharmacology

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Database: MEDLINE Therapeutic Methods and Therapies TCIM: Terapias_biologicas Main subject: Plants, Medicinal / Protease Inhibitors / Triterpenes / Candida albicans / Aspartic Acid Endopeptidases / Lycopodiaceae / Enzyme Inhibitors / Antifungal Agents Country/Region as subject: America do sul / Peru Language: En Journal: J Nat Prod Year: 2002 Type: Article Affiliation country: United States

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