House dust mite allergens induce proinflammatory cytokines from respiratory epithelial cells: the cysteine protease allergen, Der p 1, activates protease-activated receptor (PAR)-2 and inactivates PAR-1.

Asokananthan, Nithiananthan; Graham, Peter T; Stewart, David J; Bakker, Anthony J; Eidne, Karin A; Thompson, Philip J; Stewart, Geoffrey A

Asokananthan, Nithiananthan; Graham, Peter T; Stewart, David J; Bakker, Anthony J; Eidne, Karin A; Thompson, Philip J; Stewart, Geoffrey A.

Affiliation

Asokananthan N; School of Biomedical and Chemical Sciences, University of Western Australia, 35 Stirling Highway, Crawley, Perth, Western Australia 6009.

J Immunol ; 169(8): 4572-8, 2002 Oct 15.

Article in En | MEDLINE | ID: mdl-12370395

Subject(s)

Allergens/pharmacology; Antigens, Dermatophagoides/pharmacology; Dermatophagoides pteronyssinus/immunology; Receptors, Thrombin/antagonists & inhibitors; Receptors, Thrombin/metabolism; Respiratory Mucosa/immunology; Respiratory Mucosa/metabolism; Amino Acid Sequence; Animals; Arthropod Proteins; Bacterial Proteins/genetics; Bacterial Proteins/metabolism; Calcium/metabolism; Cysteine Endopeptidases/metabolism; DNA, Complementary/genetics; HeLa Cells/metabolism; Humans; Interleukin-6/antagonists & inhibitors; Interleukin-6/metabolism; Interleukin-8/antagonists & inhibitors; Interleukin-8/metabolism; Luminescent Proteins/genetics; Luminescent Proteins/metabolism; Molecular Sequence Data; Peptides/agonists; Peptides/physiology; Receptor, PAR-1; Receptor, PAR-2; Receptors, Thrombin/agonists; Receptors, Thrombin/biosynthesis; Receptors, Thrombin/genetics; Respiratory Mucosa/cytology; Respiratory Mucosa/enzymology; Transfection; Tumor Cells, Cultured/immunology; Tumor Cells, Cultured/metabolism

Search on Google

Add to My VHL

XML

PubMed Links

Database: MEDLINE Main subject: Allergens / Receptors, Thrombin / Respiratory Mucosa / Dermatophagoides pteronyssinus / Antigens, Dermatophagoides Language: En Journal: J Immunol Year: 2002 Type: Article

Search on Google

Add to My VHL

XML

PubMed Links