Altered tetrahydrobiopterin metabolism in atherosclerosis: implications for use of oxidized tetrahydrobiopterin analogues and thiol antioxidants.

Vásquez-Vivar, Jeannette; Duquaine, Damon; Whitsett, Jennifer; Kalyanaraman, B; Rajagopalan, Sanjay

Vásquez-Vivar, Jeannette; Duquaine, Damon; Whitsett, Jennifer; Kalyanaraman, B; Rajagopalan, Sanjay.

Affiliation

Vásquez-Vivar J; Biophysics Research Institute, Medical College of Wisconsin, Milwaukee, USA.

Arterioscler Thromb Vasc Biol ; 22(10): 1655-61, 2002 Oct 01.

Article in En | MEDLINE | ID: mdl-12377745

Subject(s)

Antioxidants/metabolism; Arteriosclerosis/metabolism; Biopterins/analogs & derivatives; Biopterins/metabolism; Pterins; Sulfhydryl Compounds/metabolism; Acetylcholine/pharmacology; Acetylcysteine/pharmacology; Animals; Aorta, Thoracic/chemistry; Aorta, Thoracic/drug effects; Aorta, Thoracic/enzymology; Aorta, Thoracic/pathology; Arteriosclerosis/enzymology; Arteriosclerosis/pathology; Calcimycin/pharmacology; Cholesterol/blood; Diet; Endothelium, Vascular/drug effects; Endothelium, Vascular/enzymology; Free Radical Scavengers/pharmacology; Hyperlipidemias/enzymology; Hyperlipidemias/metabolism; Hyperlipidemias/pathology; Ionophores/pharmacology; Male; Muscle, Smooth, Vascular/drug effects; Muscle, Smooth, Vascular/enzymology; Nitric Oxide/metabolism; Nitric Oxide Synthase/metabolism; Nitric Oxide Synthase/physiology; Nitric Oxide Synthase Type III; Oxidation-Reduction; Oxygen/metabolism; Pteridines/pharmacology; Rabbits; Vasodilator Agents/pharmacology

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Database: MEDLINE Main subject: Arteriosclerosis / Pterins / Sulfhydryl Compounds / Biopterins / Antioxidants Language: En Journal: Arterioscler Thromb Vasc Biol Year: 2002 Type: Article Affiliation country: United States

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