Aldehyde Oxidoreductases/physiology; Tretinoin/metabolism; Administration, Oral; Aldehyde Oxidoreductases/deficiency; Aldehyde Oxidoreductases/genetics; Animals; Ear, Inner/embryology; Ear, Inner/metabolism; Epithelial Cells/metabolism; Eye/embryology; Eye/metabolism; Female; Fetal Diseases/drug therapy; Gene Expression Regulation, Developmental; Genes, Lethal; Genes, Reporter; Gestational Age; Lac Operon; Mesonephros/metabolism; Mice; Mice, Knockout; Mice, Transgenic; Nasal Mucosa/embryology; Nasal Mucosa/metabolism; Organ Specificity; Pregnancy; Prosencephalon/embryology; Prosencephalon/metabolism; Rhombencephalon/embryology; Rhombencephalon/metabolism; Spinal Cord/embryology; Spinal Cord/metabolism; Tretinoin/therapeutic use