A novel antiinflammatory maintains glucocorticoid efficacy with reduced side effects.

Coghlan, Michael J; Jacobson, Peer B; Lane, Ben; Nakane, Masaki; Lin, Chun Wei; Elmore, Steven W; Kym, Philip R; Luly, Jay R; Carter, George W; Turner, Russell; Tyree, Curtis M; Hu, Junlian; Elgort, Marc; Rosen, Jon; Miner, Jeffrey N

Coghlan, Michael J; Jacobson, Peer B; Lane, Ben; Nakane, Masaki; Lin, Chun Wei; Elmore, Steven W; Kym, Philip R; Luly, Jay R; Carter, George W; Turner, Russell; Tyree, Curtis M; Hu, Junlian; Elgort, Marc; Rosen, Jon; Miner, Jeffrey N.

Affiliation

Coghlan MJ; Abbott Laboratories, Abbott Park, Illinois 60064, USA.

Mol Endocrinol ; 17(5): 860-9, 2003 May.

Article in En | MEDLINE | ID: mdl-12586843

Subject(s)

Anti-Inflammatory Agents, Non-Steroidal/pharmacology; Benzopyrans/pharmacology; Quinolines/pharmacology; Animals; Anti-Inflammatory Agents, Non-Steroidal/adverse effects; Anti-Inflammatory Agents, Non-Steroidal/metabolism; Arthritis, Experimental/drug therapy; Benzopyrans/adverse effects; Benzopyrans/metabolism; Bone and Bones/drug effects; Cells, Cultured; Drug Evaluation, Preclinical/methods; Edema/drug therapy; Gene Expression Regulation/drug effects; Glucocorticoids/pharmacology; Humans; Inflammation/drug therapy; Male; Nuclear Receptor Coactivator 2; Prednisolone/metabolism; Prednisolone/pharmacology; Quinolines/adverse effects; Quinolines/metabolism; Rats; Rats, Sprague-Dawley; Tibia/anatomy & histology; Tibia/drug effects; Transcription Factors/drug effects; Transcription Factors/genetics; Transcription Factors/metabolism

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Database: MEDLINE Main subject: Quinolines / Benzopyrans / Anti-Inflammatory Agents, Non-Steroidal Language: En Journal: Mol Endocrinol Year: 2003 Type: Article Affiliation country: United States

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