The regional pattern of retinoic acid synthesis by RALDH2 is essential for the development of posterior pharyngeal arches and the enteric nervous system.

Niederreither, Karen; Vermot, Julien; Le Roux, Isabelle; Schuhbaur, Brigitte; Chambon, Pierre; Dollé, Pascal

Niederreither, Karen; Vermot, Julien; Le Roux, Isabelle; Schuhbaur, Brigitte; Chambon, Pierre; Dollé, Pascal.

Affiliation

Niederreither K; Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP/Collège de France, BP 10142, 67404 Illkirch Cedex, CU de Strasbourg, France.

Development ; 130(11): 2525-34, 2003 Jun.

Article in En | MEDLINE | ID: mdl-12702665

Subject(s)

Aldehyde Oxidoreductases/metabolism; Branchial Region/embryology; Enteric Nervous System/embryology; Tretinoin/metabolism; Aldehyde Oxidoreductases/deficiency; Aldehyde Oxidoreductases/genetics; Animals; Branchial Region/drug effects; Branchial Region/metabolism; Cell Movement; Cranial Nerves/abnormalities; Cranial Nerves/embryology; DiGeorge Syndrome/etiology; Endoderm/metabolism; Enteric Nervous System/metabolism; Female; Gene Expression Regulation, Developmental; Hirschsprung Disease/etiology; Humans; Maternal-Fetal Exchange; Mesoderm/metabolism; Mice; Mice, Knockout; Mice, Transgenic; Neural Crest/cytology; Phenotype; Pregnancy; Rhombencephalon/embryology; Signal Transduction; Tretinoin/administration & dosage; Vagus Nerve/embryology

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Database: MEDLINE Main subject: Tretinoin / Branchial Region / Enteric Nervous System / Aldehyde Oxidoreductases Type of study: Etiology_studies Language: En Journal: Development Year: 2003 Type: Article Affiliation country: France

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