Methanol extract of Cordyceps pruinosa inhibits in vitro and in vivo inflammatory mediators by suppressing NF-kappaB activation.

Kim, Ki-Mo; Kwon, Young-Guen; Chung, Hun-Taeg; Yun, Young-Gab; Pae, Hyun-Ock; Han, Jeong A; Ha, Kwon Soo; Kim, Tae-Woong; Kim, Young-Myeong

Kim, Ki-Mo; Kwon, Young-Guen; Chung, Hun-Taeg; Yun, Young-Gab; Pae, Hyun-Ock; Han, Jeong A; Ha, Kwon Soo; Kim, Tae-Woong; Kim, Young-Myeong.

Affiliation

Kim KM; Department of Molecular and Cellular Biochemistry, School of Medicine, Kangwon National University, Chunchon, Kangwon-Do 200-701, South Korea.

Toxicol Appl Pharmacol ; 190(1): 1-8, 2003 Jul 01.

Article in En | MEDLINE | ID: mdl-12831777

Subject(s)

Cordyceps/chemistry; Inflammation Mediators/antagonists & inhibitors; NF-kappa B/antagonists & inhibitors; Animals; Blotting, Western; Cell Line; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors/pharmacology; Dinoprostone/biosynthesis; Electrophoretic Mobility Shift Assay; Enzyme Inhibitors/pharmacology; Female; Interleukin-1/antagonists & inhibitors; Interleukin-1/biosynthesis; Isoenzymes/metabolism; Lipopolysaccharides/pharmacology; Macrophages/drug effects; Macrophages/metabolism; Methanol; Mice; Mice, Inbred BALB C; NF-kappa B/metabolism; Nitric Oxide/biosynthesis; Nitric Oxide Synthase/antagonists & inhibitors; Nitric Oxide Synthase Type II; Plant Extracts/pharmacology; Prostaglandin-Endoperoxide Synthases/metabolism; Reverse Transcriptase Polymerase Chain Reaction; Solvents; Tumor Necrosis Factor-alpha/antagonists & inhibitors; Tumor Necrosis Factor-alpha/biosynthesis

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Database: MEDLINE Main subject: NF-kappa B / Inflammation Mediators / Cordyceps Language: En Journal: Toxicol Appl Pharmacol Year: 2003 Type: Article Affiliation country: South Korea

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