In vitro drug interactions of cytochrome p450: an evaluation of fluorogenic to conventional substrates.

Cohen, Lawrence H; Remley, Michael J; Raunig, David; Vaz, Alfin D N

Cohen, Lawrence H; Remley, Michael J; Raunig, David; Vaz, Alfin D N.

Affiliation

Cohen LH; Pfizer Global Research and Development, Groton, Connecticut 06340-5146, USA. larry_cohen@groton.pfizer.com

Drug Metab Dispos ; 31(8): 1005-15, 2003 Aug.

Article in En | MEDLINE | ID: mdl-12867489

Subject(s)

Cytochrome P-450 Enzyme System/drug effects; Cytochrome P-450 Enzyme System/metabolism; Chemistry, Pharmaceutical; Cytochrome P-450 Enzyme Inhibitors; Drug Evaluation, Preclinical; Drug Industry; Drug Interactions; Fluorescent Dyes/economics; Fluorescent Dyes/metabolism; Guidelines as Topic; Inhibitory Concentration 50; Research Design; Structure-Activity Relationship

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Database: MEDLINE Main subject: Cytochrome P-450 Enzyme System Type of study: Evaluation_studies / Guideline Language: En Journal: Drug Metab Dispos Year: 2003 Type: Article Affiliation country: United States

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