Fangchinoline inhibits rat aortic vascular smooth muscle cell proliferation and cell cycle progression through inhibition of ERK1/2 activation and c-fos expression.

Zhang, Yong-He; Fang, Lian-Hua; Ku, Bao-Shan

Zhang, Yong-He; Fang, Lian-Hua; Ku, Bao-Shan.

Affiliation

Zhang YH; Department of Pharmacology, School of Basic Medical Science, Peking University, Beijing, PR China. yhzhpku@bjmu.edu.cn

Biochem Pharmacol ; 66(9): 1853-60, 2003 Nov 01.

Article in En | MEDLINE | ID: mdl-14563495

Subject(s)

Alkaloids/pharmacology; Benzylisoquinolines/pharmacology; Cell Cycle/drug effects; Mitogen-Activated Protein Kinases/metabolism; Muscle, Smooth, Vascular/drug effects; Proto-Oncogene Proteins c-fos/metabolism; Animals; Aorta/cytology; Cell Division/drug effects; Cells, Cultured; DNA/biosynthesis; DNA/drug effects; Drugs, Chinese Herbal/pharmacology; Enzyme Activation/drug effects; Gene Expression/drug effects; Male; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases/metabolism; Muscle, Smooth, Vascular/cytology; Muscle, Smooth, Vascular/enzymology; Phosphorylation/drug effects; Rats; Rats, Sprague-Dawley

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Database: MEDLINE Traditional Medicines: Medicinas_tradicionales_de_asia / Medicina_china Main subject: Cell Cycle / Proto-Oncogene Proteins c-fos / Mitogen-Activated Protein Kinases / Benzylisoquinolines / Alkaloids / Muscle, Smooth, Vascular Language: En Journal: Biochem Pharmacol Year: 2003 Type: Article

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