Chronic subthalamic nucleus stimulation and striatal D2 dopamine receptors in Parkinson's disease--A [(11)C]-raclopride PET study.
J Neurol
; 250(10): 1219-23, 2003 Oct.
Article
in En
| MEDLINE
| ID: mdl-14586606
ABSTRACT
CONTEXT Subthalamic nucleus (STN) stimulation mechanism of action remains a matter for debate. In animals, an increased striatal dopamine (DA) release due to STN stimulation has been reported. OBJECTIVE:
To determine in Parkinson's disease (PD) patients using positron emission tomography (PET) and [11C]-Raclopride, whether STN stimulation induces a striatal DA release.METHODS:
Nine PD patients with bilateral STN stimulation were enrolled and underwent two [11C]-Raclopride PET scans. The scans were randomly performed in off and on stimulation conditions. Striatal [11C]-Raclopride binding potential (BP) was calculated using regions of interest and statistical parametric mapping.RESULTS:
For PD patients, the mean [(11C]-Raclopride BP (+/- SD) were, in Off stimulation condition 1.7 +/- 0.3 for the right caudate nucleus, 1.8 +/- 0.4 for the left caudate nucleus, 2.6 +/- 0.5 for the right putamenand 2.6 +/- 0.5 for the left putamen. In On stimulation condition 1.7 +/- 0.4 for the right caudate nucleus, 1.9 +/- 0.5 for the left caudate nucleus, 2.8 +/- 0.7 for the right putamen and 2.7 +/- 0.8 for the left putamen. No significant difference of BP related to the stimulation was noted.CONCLUSION:
STN stimulation does not produce significant variations of striatal DA release as assessed by PET and [11C]-Raclopride.
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Database:
MEDLINE
Main subject:
Parkinson Disease
/
Dopamine
/
Electric Stimulation Therapy
/
Receptors, Dopamine D2
/
Dopamine Antagonists
/
Subthalamic Nucleus
/
Raclopride
Language:
En
Journal:
J Neurol
Year:
2003
Type:
Article
Affiliation country:
France