CYP2U1, a novel human thymus- and brain-specific cytochrome P450, catalyzes omega- and (omega-1)-hydroxylation of fatty acids.

Chuang, Samuel S; Helvig, Christian; Taimi, Mohammed; Ramshaw, Heather A; Collop, Andrew H; Amad, Ma'an; White, Jay A; Petkovich, Martin; Jones, Glenville; Korczak, Bozena

Chuang, Samuel S; Helvig, Christian; Taimi, Mohammed; Ramshaw, Heather A; Collop, Andrew H; Amad, Ma'an; White, Jay A; Petkovich, Martin; Jones, Glenville; Korczak, Bozena.

Affiliation

Chuang SS; Cytochroma, Inc, Markham, Ontario L3R 8E4, Canada.

J Biol Chem ; 279(8): 6305-14, 2004 Feb 20.

Article in En | MEDLINE | ID: mdl-14660610

Subject(s)

Brain/enzymology; Cytochrome P-450 CYP4A/metabolism; Cytochrome P-450 Enzyme System/biosynthesis; Cytochrome P-450 Enzyme System/chemistry; Fatty Acids/chemistry; Mixed Function Oxygenases/biosynthesis; Mixed Function Oxygenases/chemistry; Thymus Gland/enzymology; Amino Acid Sequence; Animals; Arachidonic Acids/metabolism; Baculoviridae; Base Sequence; Blotting, Western; Catalysis; Cell Line; Chromatography, Liquid; Cytochrome P450 Family 2; DNA, Complementary/metabolism; Expressed Sequence Tags; Humans; Hydroxyeicosatetraenoic Acids/chemistry; Immunoblotting; Insecta; Mass Spectrometry; Microsomes/metabolism; Molecular Sequence Data; Multigene Family; Phylogeny; Protein Structure, Tertiary; RNA, Messenger/metabolism; Recombinant Proteins/chemistry; Recombinant Proteins/metabolism; Signal Transduction; Substrate Specificity; Thymus Gland/metabolism; Time Factors; Tissue Distribution; alpha-Linolenic Acid/chemistry

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Database: MEDLINE Main subject: Thymus Gland / Brain / Cytochrome P-450 Enzyme System / Cytochrome P-450 CYP4A / Fatty Acids / Mixed Function Oxygenases Type of study: Prognostic_studies Language: En Journal: J Biol Chem Year: 2004 Type: Article Affiliation country: Canada

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