Endothelium-dependent vascular relaxation induced by Eucommia ulmoides Oliv. bark extract is mediated by NO and EDHF in small vessels.

Kwan, Chiu-Yin; Zhang, Wen-Bo; Deyama, Takeshi; Nishibe, Sansei

Kwan, Chiu-Yin; Zhang, Wen-Bo; Deyama, Takeshi; Nishibe, Sansei.

Affiliation

Kwan CY; HSC-4N40, Department of Medicine, Faculty of Health Sciences, McMaster University, 1200 Main Street West, L8N 3Z5, Hamilton, Ontario, Canada. kwancy@mcmaster.ca

Naunyn Schmiedebergs Arch Pharmacol ; 369(2): 206-11, 2004 Feb.

Article in En | MEDLINE | ID: mdl-14673511

Subject(s)

Biological Factors/metabolism; Endothelium, Vascular/drug effects; Eucommiaceae/chemistry; Nitric Oxide/metabolism; Vasodilator Agents/pharmacology; Animals; Aorta, Thoracic/drug effects; Aorta, Thoracic/physiology; Dose-Response Relationship, Drug; Drugs, Chinese Herbal/administration & dosage; Drugs, Chinese Herbal/pharmacology; Endothelium, Vascular/physiology; In Vitro Techniques; Male; Mesenteric Arteries/drug effects; Mesenteric Arteries/physiology; Muscle Relaxation/drug effects; Muscle, Smooth, Vascular/drug effects; Muscle, Smooth, Vascular/physiology; NG-Nitroarginine Methyl Ester/metabolism; Plant Bark/chemistry; Plant Leaves/chemistry; Rats; Rats, Sprague-Dawley; Vasodilator Agents/administration & dosage

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Database: MEDLINE Traditional Medicines: Medicinas_tradicionales_de_asia / Medicina_china Main subject: Vasodilator Agents / Endothelium, Vascular / Biological Factors / Eucommiaceae / Nitric Oxide Language: En Journal: Naunyn Schmiedebergs Arch Pharmacol Year: 2004 Type: Article Affiliation country: Canada

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