Five new maleic and succinic acid derivatives from the mycelium of Antrodia camphorata and their cytotoxic effects on LLC tumor cell line.

Nakamura, Norio; Hirakawa, Akiko; Gao, Jiang-Jing; Kakuda, Hiroko; Shiro, Motoo; Komatsu, Yasuhiro; Sheu, Chia-chin; Hattori, Masao

Nakamura, Norio; Hirakawa, Akiko; Gao, Jiang-Jing; Kakuda, Hiroko; Shiro, Motoo; Komatsu, Yasuhiro; Sheu, Chia-chin; Hattori, Masao.

Affiliation

Nakamura N; Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-0194, Japan.

J Nat Prod ; 67(1): 46-8, 2004 Jan.

Article in En | MEDLINE | ID: mdl-14738384

ABSTRACT

ABSTRACT

Five new maleic and succinic acid derivatives were isolated from the mycelium of Antrodia camphorata. Their structures were determined by various spectroscopic means. Maleimide derivatives 2 and 3 showed appreciable cytotoxic activity against LLC cells.

Subject(s)

Antineoplastic Agents/isolation & purification; Maleates/isolation & purification; Polyporaceae/chemistry; Succinic Acid/isolation & purification; Antineoplastic Agents/chemistry; Antineoplastic Agents/pharmacology; Crystallography, X-Ray; Drug Screening Assays, Antitumor; Maleates/chemistry; Maleates/pharmacology; Medicine, Chinese Traditional; Molecular Structure; Succinic Acid/chemistry; Succinic Acid/pharmacology; Taiwan; Tumor Cells, Cultured

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Database: MEDLINE Traditional Medicines: Medicinas_tradicionales_de_asia / Medicina_china Main subject: Polyporaceae / Succinic Acid / Maleates / Antineoplastic Agents Type of study: Diagnostic_studies Country/Region as subject: Asia Language: En Journal: J Nat Prod Year: 2004 Type: Article Affiliation country: Japan

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