Increased myocardial dysfunction after ischemia-reperfusion in mice lacking glucose-6-phosphate dehydrogenase.

Jain, Mohit; Cui, Lei; Brenner, Daniel A; Wang, Bo; Handy, Diane E; Leopold, Jane A; Loscalzo, Joseph; Apstein, Carl S; Liao, Ronglih

Jain, Mohit; Cui, Lei; Brenner, Daniel A; Wang, Bo; Handy, Diane E; Leopold, Jane A; Loscalzo, Joseph; Apstein, Carl S; Liao, Ronglih.

Affiliation

Jain M; Whitaker Cardiovascular Institute and Evans Department of Medicine, Boston University School of Medicine, Boston, Mass 02118, USA.

Circulation ; 109(7): 898-903, 2004 Feb 24.

Article in En | MEDLINE | ID: mdl-14757696

Subject(s)

Glucosephosphate Dehydrogenase Deficiency/complications; Glucosephosphate Dehydrogenase/physiology; Myocardial Contraction/physiology; Myocardial Ischemia/genetics; Myocardial Reperfusion Injury/genetics; Animals; Antioxidants/pharmacology; Antioxidants/therapeutic use; Female; Genotype; Glucosephosphate Dehydrogenase/genetics; Glutathione/metabolism; Male; Metalloporphyrins/pharmacology; Metalloporphyrins/therapeutic use; Mice; Mice, Knockout; Myocardial Contraction/drug effects; Myocardial Ischemia/enzymology; Myocardial Ischemia/physiopathology; Myocardial Reperfusion Injury/enzymology; Myocardial Reperfusion Injury/physiopathology; NADP/physiology; Oxidation-Reduction; Ribose/deficiency; Ribose/pharmacology

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Database: MEDLINE Main subject: Myocardial Reperfusion Injury / Myocardial Ischemia / Glucosephosphate Dehydrogenase / Glucosephosphate Dehydrogenase Deficiency / Myocardial Contraction Language: En Journal: Circulation Year: 2004 Type: Article Affiliation country: United States

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