Molecular determinants of vanilloid sensitivity in TRPV1.

Gavva, Narender R; Klionsky, Lana; Qu, Yusheng; Shi, Licheng; Tamir, Rami; Edenson, Steve; Zhang, T J; Viswanadhan, Vellarkad N; Toth, Attila; Pearce, Larry V; Vanderah, Todd W; Porreca, Frank; Blumberg, Peter M; Lile, Jack; Sun, Yax; Wild, Ken; Louis, Jean-Claude; Treanor, James J S

Gavva, Narender R; Klionsky, Lana; Qu, Yusheng; Shi, Licheng; Tamir, Rami; Edenson, Steve; Zhang, T J; Viswanadhan, Vellarkad N; Toth, Attila; Pearce, Larry V; Vanderah, Todd W; Porreca, Frank; Blumberg, Peter M; Lile, Jack; Sun, Yax; Wild, Ken; Louis, Jean-Claude; Treanor, James J S.

Affiliation

Gavva NR; Department of Neuroscience, Amgen Inc., MS 29-2 B, One Amgen Center Drive, Thousand Oaks, CA 91320-1799, USA. ngavva@amgen.com

J Biol Chem ; 279(19): 20283-95, 2004 May 07.

Article in En | MEDLINE | ID: mdl-14996838

Subject(s)

Receptors, Drug/genetics; Receptors, Drug/metabolism; Receptors, Drug/physiology; Amino Acid Sequence; Animals; CHO Cells; Calcium/metabolism; Capsaicin/pharmacology; Cations; Cell Line; Cloning, Molecular; Cricetinae; DNA, Complementary/metabolism; Dose-Response Relationship, Drug; Electrophysiology; Ganglia, Spinal/metabolism; Hot Temperature; Humans; Hydrogen-Ion Concentration; In Situ Hybridization; Inhibitory Concentration 50; Ligands; Methionine/chemistry; Models, Molecular; Molecular Sequence Data; Mutation; Neurons/metabolism; Phorbol Esters/pharmacology; Phylogeny; Protein Binding; Protein Structure, Tertiary; Protons; Rabbits; Rats; Receptors, Drug/chemistry; Sequence Homology, Amino Acid; Serine/chemistry; Temperature; Threonine/chemistry; Transfection; Tyrosine/chemistry

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Database: MEDLINE Main subject: Receptors, Drug Type of study: Diagnostic_studies / Prognostic_studies Language: En Journal: J Biol Chem Year: 2004 Type: Article Affiliation country: United States

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