Angiogenesis and anti-angiogenesis activity of Chinese medicinal herbal extracts.
Life Sci
; 74(20): 2467-78, 2004 Apr 02.
Article
in En
| MEDLINE
| ID: mdl-15010258
ABSTRACT
The aqueous extracts of 24 herbs traditionally used as curing ischemic heart disease in clinic in China were screened for their in vitro angiogenic activity, another twenty-four traditionally used as anti-tumor or anti-inflammatory remedies in China were screened for their in vitro anti-angiogenic activity. The activity of angiogenesis was determined by quantitation of vessels on chick embryo chorioallantoic membrane (CAM) model and cell proliferation of cultured bovine aortic endothelial cells (BAECs). Among the herbal extracts examined, the aqueous extracts of Epimedium sagittatum, Trichosanthes kirilowii and Dalbergia odorifera showed the strong angiogenetic activity both in CAM and BAECs models; and the aqueous extracts of Berberis paraspecta, Catharanthus roseus, Coptis chinensis, Taxus chinensis, Scutellaria baicalensis, Polygonum cuspidatum and Scrophularia ningpoensis elicited significant inhibition at a concentration of 1g dry herb /ml.
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Database:
MEDLINE
Traditional Medicines:
Medicinas_tradicionales_de_asia
/
Medicina_china
Therapeutic Methods and Therapies TCIM:
Terapias_biologicas
/
Plantas_medicinales
Main subject:
Drugs, Chinese Herbal
/
Plant Extracts
/
Neovascularization, Physiologic
/
Angiogenesis Inhibitors
/
Angiogenesis Inducing Agents
/
Neovascularization, Pathologic
Type of study:
Diagnostic_studies
/
Prognostic_studies
Language:
En
Journal:
Life Sci
Year:
2004
Type:
Article
Affiliation country:
China