Orexins (hypocretins) directly interact with neuropeptide Y, POMC and glucose-responsive neurons to regulate Ca 2+ signaling in a reciprocal manner to leptin: orexigenic neuronal pathways in the mediobasal hypothalamus.

Muroya, Shinji; Funahashi, Hisayuki; Yamanaka, Akihiro; Kohno, Daisuke; Uramura, Kazuhide; Nambu, Tadahiro; Shibahara, Megumi; Kuramochi, Motoki; Takigawa, Morikuni; Yanagisawa, Masashi; Sakurai, Takeshi; Shioda, Seiji; Yada, Toshihiko

Muroya, Shinji; Funahashi, Hisayuki; Yamanaka, Akihiro; Kohno, Daisuke; Uramura, Kazuhide; Nambu, Tadahiro; Shibahara, Megumi; Kuramochi, Motoki; Takigawa, Morikuni; Yanagisawa, Masashi; Sakurai, Takeshi; Shioda, Seiji; Yada, Toshihiko.

Affiliation

Muroya S; Department of Physiology, Division of Integrative Physiology, Jichi Medical School, Minamikawachi, Kawachi, Tochigi 329-0498, Japan.

Eur J Neurosci ; 19(6): 1524-34, 2004 Mar.

Article in En | MEDLINE | ID: mdl-15066149

Subject(s)

Calcium Signaling/drug effects; Carrier Proteins/pharmacology; Glucose/metabolism; Hypothalamus/cytology; Intracellular Signaling Peptides and Proteins; Leptin/pharmacology; Neuropeptide Y/metabolism; Neuropeptides/pharmacology; Pro-Opiomelanocortin/metabolism; Animals; Dose-Response Relationship, Drug; Drug Interactions; Eating/drug effects; Enzyme Inhibitors; Fura-2/metabolism; Immunohistochemistry; Models, Neurological; Neurons/classification; Neurons/drug effects; Neurons/metabolism; Orexins; Pertussis Toxin/pharmacology; Rats; Rats, Sprague-Dawley; gamma-Aminobutyric Acid/pharmacology

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Database: MEDLINE Complementary Medicines: Homeopatia Main subject: Neuropeptide Y / Neuropeptides / Pro-Opiomelanocortin / Carrier Proteins / Calcium Signaling / Leptin / Intracellular Signaling Peptides and Proteins / Glucose / Hypothalamus Type of study: Prognostic_studies Language: En Journal: Eur J Neurosci Year: 2004 Type: Article Affiliation country: Japan

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