beta-Carotene exacerbates DNA oxidative damage and modifies p53-related pathways of cell proliferation and apoptosis in cultured cells exposed to tobacco smoke condensate.

Palozza, Paola; Serini, Simona; Di Nicuolo, Fiorella; Boninsegna, Alma; Torsello, Angela; Maggiano, Nicola; Ranelletti, Franco O; Wolf, Federica I; Calviello, Gabriella; Cittadini, Achille

Palozza, Paola; Serini, Simona; Di Nicuolo, Fiorella; Boninsegna, Alma; Torsello, Angela; Maggiano, Nicola; Ranelletti, Franco O; Wolf, Federica I; Calviello, Gabriella; Cittadini, Achille.

Affiliation

Palozza P; Institute of General Pathology, Catholic University, Rome, Italy. p.palozza@rm.unicatt.it

Carcinogenesis ; 25(8): 1315-25, 2004 Aug.

Article in En | MEDLINE | ID: mdl-15073048

Subject(s)

DNA Damage; Deoxyguanosine/analogs & derivatives; Nicotiana/adverse effects; Oxygen/metabolism; Proto-Oncogene Proteins c-bcl-2; Tumor Suppressor Protein p53/physiology; beta Carotene/physiology; 8-Hydroxy-2'-Deoxyguanosine; Animals; Apoptosis; Blotting, Western; Cell Cycle/drug effects; Cell Division; Cell Line, Tumor; Cells, Cultured; Cyclin D1/biosynthesis; Deoxyguanosine/biosynthesis; Dose-Response Relationship, Drug; Fibroblasts/drug effects; Fibroblasts/metabolism; G1 Phase; Humans; Mice; Oxidative Stress; Proto-Oncogene Proteins/metabolism; Rats; Resting Phase, Cell Cycle; Smoking/adverse effects; Time Factors; Tumor Suppressor Protein p53/metabolism; bcl-2-Associated X Protein

Search on Google

Add to My VHL

XML

PubMed Links

Database: MEDLINE Main subject: Oxygen / Nicotiana / DNA Damage / Tumor Suppressor Protein p53 / Beta Carotene / Proto-Oncogene Proteins c-bcl-2 / Deoxyguanosine Language: En Journal: Carcinogenesis Year: 2004 Type: Article Affiliation country: Italy

Search on Google

Add to My VHL

XML

PubMed Links