[Rehabilitation therapy of convalescents after hemorrhagic fever with renal syndrome in outpatient clinic]. / Vosstanovitel'noe lechenie v usloviiakh polikliniki rekonvalestsentov, perenesshikh gemorragicheskuiu likhoradku s pochechnym simdromom.
Ter Arkh
; 76(1): 17-22, 2004.
Article
in Ru
| MEDLINE
| ID: mdl-15108430
ABSTRACT
AIM:
To assess clinical efficacy of mineral water and perindopril in convalescents after hemorrhagic fever with renal syndrome (HFRS) in outpatient setting. MATERIAL ANDMETHODS:
The study covered 113 HFRS convalescents. HFRS was confirmed serologically. The patients were divided into three groups group 1 (n = 50) received no rehabilitation care; group 2 (n = 32) drank mineral water "varzi-yatchi"; group 3 (n = 31) drank mineral water and took perindopril (2 mg/day). After-treatment continued for 30-35 days. The effect was assessed by a complex of clinical-laboratory and functional tests for examination of renal functions (Reberg-Tareev, Zimnitsky tests, estimation of uric acid clearance and renal functional reserve, an 18-hour water deprivation test).RESULTS:
Mineral water varzi-yatchi and perindopril had a favourable effect on clinical condition and renal functions of HFRS convalescents. Compared to the controls (p < 0.05), they had less severe weakness, lumbar pains, edema of the lower limbs; positive changes in intraglomerular hemodynamics, renal transport of beta 2-microglobulin (MG), uric acid transport.CONCLUSION:
It is shown that HFRS convalescents have defective glomerular and tubulointerstitial systems of the kidneys. These disorders demand a differential therapeutic approach. Drinking mineral water improves some tubular functions. The addition of perindopril is necessary in detection of arterial hypertension, impairment of intraglomerular hemodynamics, hyperexcretion of beta 2-MG, osmoregulating renal dysfunction.
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Database:
MEDLINE
Therapeutic Methods and Therapies TCIM:
Terapias_biologicas
/
Hidroterapia
/
Termalismo
Main subject:
Perindopril
/
Hemorrhagic Fever with Renal Syndrome
/
Kidney
/
Mineral Waters
Language:
Ru
Journal:
Ter Arkh
Year:
2004
Type:
Article