Suppressors of T-cell receptor signaling Sts-1 and Sts-2 bind to Cbl and inhibit endocytosis of receptor tyrosine kinases.

Kowanetz, Katarzyna; Crosetto, Nicola; Haglund, Kaisa; Schmidt, Mirko; Heldin, Carl-Henrik; Dikic, Ivan

Kowanetz, Katarzyna; Crosetto, Nicola; Haglund, Kaisa; Schmidt, Mirko; Heldin, Carl-Henrik; Dikic, Ivan.

Affiliation

Kowanetz K; Institute of Biochemistry II, Goethe University Medical School, 60590 Frankfurt, Germany.

J Biol Chem ; 279(31): 32786-95, 2004 07 30.

Article in En | MEDLINE | ID: mdl-15159412

Subject(s)

Carrier Proteins/metabolism; Proto-Oncogene Proteins/metabolism; T-Lymphocytes/metabolism; Ubiquitin-Protein Ligases/metabolism; Amino Acid Sequence; Animals; CHO Cells; COS Cells; Cell Division; Cell Line; Cell Transformation, Neoplastic; Cricetinae; DNA, Complementary/metabolism; Dimerization; Down-Regulation; Endocytosis; ErbB Receptors/metabolism; Glutathione Transferase/metabolism; Humans; Ligands; Membrane Proteins; Mice; Molecular Sequence Data; NIH 3T3 Cells; Phosphoglycerate Mutase/chemistry; Protein Binding; Protein Structure, Tertiary; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins c-cbl; Receptor Protein-Tyrosine Kinases/metabolism; Receptors, Antigen, T-Cell/metabolism; Sequence Homology, Amino Acid; Signal Transduction; Thymidine/metabolism; Time Factors; src Homology Domains

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Database: MEDLINE Main subject: T-Lymphocytes / Carrier Proteins / Proto-Oncogene Proteins / Ubiquitin-Protein Ligases Type of study: Prognostic_studies Language: En Journal: J Biol Chem Year: 2004 Type: Article Affiliation country: Germany

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