Discovery of glycine hydrazide pore-occluding CFTR inhibitors: mechanism, structure-activity analysis, and in vivo efficacy.

Muanprasat, Chatchai; Sonawane, N D; Salinas, Danieli; Taddei, Alessandro; Galietta, Luis J V; Verkman, A S

Muanprasat, Chatchai; Sonawane, N D; Salinas, Danieli; Taddei, Alessandro; Galietta, Luis J V; Verkman, A S.

Affiliation

Muanprasat C; Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143-0521, USA.

J Gen Physiol ; 124(2): 125-37, 2004 Aug.

Article in En | MEDLINE | ID: mdl-15277574

Subject(s)

Cystic Fibrosis Transmembrane Conductance Regulator/antagonists & inhibitors; Glycine/analogs & derivatives; Glycine/chemistry; Glycine/pharmacology; Animals; Cells, Cultured; Cystic Fibrosis Transmembrane Conductance Regulator/chemistry; Cystic Fibrosis Transmembrane Conductance Regulator/metabolism; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical/methods; Humans; Mice; Rats; Rats, Inbred F344; Structure-Activity Relationship

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Full text: 1 Database: MEDLINE Main subject: Cystic Fibrosis Transmembrane Conductance Regulator / Glycine Language: En Journal: J Gen Physiol Year: 2004 Type: Article Affiliation country: United States

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