Mechanisms of poly-N-acetyl glucosamine polymer-mediated hemostasis: platelet interactions.

Thatte, Hemant S; Zagarins, Sofija; Khuri, Shukri F; Fischer, Thomas H

Thatte, Hemant S; Zagarins, Sofija; Khuri, Shukri F; Fischer, Thomas H.

Affiliation

Thatte HS; Department Surgery, VA Boston Healthcare System, Brigham and Women's Hospital, Harvard Medical Schools, Boston, MA, USA.

J Trauma ; 57(1 Suppl): S13-21, 2004 Jul.

Article in En | MEDLINE | ID: mdl-15280745

Subject(s)

Acetylglucosamine/pharmacology; Blood Platelets/drug effects; Chitin/analogs & derivatives; Hemostatics/pharmacology; Platelet Activation/drug effects; Acetylglucosamine/chemistry; Blood Platelets/ultrastructure; Calcium/physiology; Chitin/chemistry; Chitin/pharmacology; Chitosan; Drug Evaluation, Preclinical; Fibrin/drug effects; Hemostasis, Surgical/methods; Hemostatics/chemistry; Humans; Integrin alpha2; Integrin alpha5/drug effects; Integrin alpha6/drug effects; Integrin beta3/drug effects; Intracellular Fluid/drug effects; Membrane Glycoproteins/drug effects; Microscopy, Electron, Scanning; Microscopy, Fluorescence, Multiphoton; P-Selectin/drug effects; Phosphatidylserines/physiology; Platelet Activation/physiology; Platelet Adhesiveness/drug effects; Platelet Glycoprotein GPIb-IX Complex/drug effects; Platelet Membrane Glycoprotein IIb/drug effects; Spectrophotometry; Time Factors

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Database: MEDLINE Main subject: Acetylglucosamine / Blood Platelets / Hemostatics / Platelet Activation / Chitin Language: En Journal: J Trauma Year: 2004 Type: Article Affiliation country: United States

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