Agrin signaling in cortical neurons is mediated by a tyrosine kinase-dependent increase in intracellular Ca2+ that engages both CaMKII and MAPK signal pathways.

Hilgenberg, Lutz G W; Smith, Martin A

Hilgenberg, Lutz G W; Smith, Martin A.

Affiliation

Hilgenberg LG; Department of Anatomy and Neurobiology, University of California, Irvine Hall, Rm 110, Irvine, California 92697, USA.

J Neurobiol ; 61(3): 289-300, 2004 Dec.

Article in En | MEDLINE | ID: mdl-15389602

Subject(s)

Agrin/metabolism; Calcium-Calmodulin-Dependent Protein Kinases/metabolism; Calcium/metabolism; Cerebral Cortex/cytology; Fura-2/analogs & derivatives; Mitogen-Activated Protein Kinases/metabolism; Neurons/enzymology; Signal Transduction/physiology; 2-Amino-5-phosphonovalerate/pharmacology; Agrin/chemistry; Agrin/pharmacology; Animals; Animals, Newborn; Blotting, Western/methods; Calcium Channel Blockers/pharmacology; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cells, Cultured; Chlorocebus aethiops; Conotoxins/pharmacology; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors/pharmacology; Excitatory Amino Acid Antagonists/pharmacology; Extracellular Space/drug effects; Extracellular Space/metabolism; Fura-2/metabolism; Glial Fibrillary Acidic Protein/metabolism; Immunohistochemistry/methods; Mice; Mice, Inbred ICR; Models, Neurological; Neurons/drug effects; Nifedipine/pharmacology; Peptide Fragments/pharmacology; Protein-Tyrosine Kinases/metabolism; Signal Transduction/drug effects; Transfection/methods; Tubocurarine/pharmacology

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Database: MEDLINE Main subject: Signal Transduction / Cerebral Cortex / Calcium / Fura-2 / Calcium-Calmodulin-Dependent Protein Kinases / Agrin / Mitogen-Activated Protein Kinases / Neurons Type of study: Prognostic_studies Language: En Journal: J Neurobiol Year: 2004 Type: Article Affiliation country: United States

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