Arteriosclerosis/genetics; Animals; Apolipoprotein A-I/administration & dosage; Apolipoprotein A-I/genetics; Apolipoprotein A-I/pharmacology; Apolipoprotein A-I/therapeutic use; Arachidonate 5-Lipoxygenase/genetics; Arachidonate 5-Lipoxygenase/physiology; Arteriosclerosis/prevention & control; Arteriosclerosis/therapy; Cohort Studies; Coronary Artery Disease/drug therapy; Coronary Artery Disease/prevention & control; Drug Evaluation, Preclinical; Genetic Predisposition to Disease; Genetic Testing; Genotype; Humans; Leukotrienes/metabolism; Life Style; Lipoproteins, HDL/blood; Lipoproteins, HDL/genetics; Lipoproteins, LDL/blood; Lipoproteins, LDL/genetics; Methylenetetrahydrofolate Reductase (NADPH2)/genetics; Methylenetetrahydrofolate Reductase (NADPH2)/physiology; Mice; Mice, Inbred C57BL; Multicenter Studies as Topic; Penetrance; Pharmacogenetics; Phospholipids/administration & dosage; Phospholipids/pharmacology; Phospholipids/therapeutic use; Polymorphism, Genetic; Promoter Regions, Genetic; Rabbits; Recombinant Proteins/administration & dosage; Recombinant Proteins/pharmacology; Recombinant Proteins/therapeutic use; Risk